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Article

Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors.

The Journal of biological chemistry - 12 Jul 2013

Musille Paul M, Pathak Manish, Lauer Janelle L, Griffin Patrick R, Ortlund Eric A

Abstract excerpt

The members of the NR5A subfamily of nuclear receptors (NRs) are important regulators of pluripotency, lipid and glucose homeostasis, and steroidogenesis. Liver receptor homologue 1 (LRH-1; NR5A2) and steroidogenic factor 1 (SF-1; NR5A1) have therapeutic potential for the treatment of metabolic a...

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Identifiers

PMID: 23737522
DOI: 10.1074/jbc.M113.472837
PMCID: PMC3711333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23737522-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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