Article
EZH2 genetic variants affect risk of gastric cancer in the Chinese Han population.
Molecular carcinogenesis - 1 Aug 2014
Zhou Yuan, Du Wei-Dong, Wu Qiang, Liu Yi, Chen Gang, Ruan Jian, Xu Song, Yang Feng, Zhou Fu-Sheng, Tang Xian-Fa, Tang Hua-Yang, Zuo Xian-Bo, Zhang Feng-Yu, Sun Liang-Dan, Zhang Xue-Jun
Abstract excerpt
Enhancer of zeste 2 (EZH2) gene encodes a histone methyltransferase that constitutes the catalytic component of the polycomb repressive complex-2 (PRC2) to initiate epigenetic silencing of genes. It is reported that the expression level of EZH2 in gastric cancer tissue was highly correlated with tumor progression, however, whether EZH2 genetic variants were associated with the risk of gastric cancer remains yet...
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