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Article

Effects of EZH2 polymorphisms on susceptibility to and pathological development of hepatocellular carcinoma.

PloS one - 1 Jan 2013

Yu Yung-Luen, Su Kuo-Jung, Hsieh Yi-Hsien, Lee Hsiang-Lin, Chen Tzy-Yen, Hsiao Pei-Ching, Yang Shun-Fa

Abstract excerpt

BACKGROUND: The enhancer of zeste 2 (EZH2) gene encodes the histone methyltransferase that is the catalytic component of the polycomb repressive complex-2, which initiates epigenetic silencing of genes. The expression level of EZH2 in hepatocellular carcinoma (HCC) is highly correlated with tumor progression; however, it has not been determined if specific EZH2 genetic variants are associated with the risk of...

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Identifiers

PMID: 24040354
DOI: 10.1371/journal.pone.0074870
PMCID: PMC3769270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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