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Article

Functional relationship of SNP (Ala490Thr) of an epigenetic gene EZH2 results in the progression and poor survival of ER+/tamoxifen treated breast cancer patients.

Journal of genetics - 1 Jan 2021

Gautam Nisha, Verma Himanshu, Choudhary Shalki, Kaur Satbir, Silakari Om

Abstract excerpt

EZH2 is a classic histone methyltransferase that causes the trimethylation of H3K27 and consequently suppresses the cancer preventive genes. The role of elevated levels of EZH2 expression in breast cancer aggressiveness and poor prognosis is very well established. The present study focusses on the insight of the clinically important SNPs of EZH2 gene in determining the structure-function relationship towards...

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PMID: 34825659

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