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Article

Mutational Analysis of EZH2 Gene in Patients with Colorectal Adenoma Reveals a Genetic Variant Associated with Risk of Malignant Transformation.

Asian Pacific journal of cancer prevention : APJCP - 1 Dec 2021

Mahasneh Amjad A, Alnegresh Faten S, Alfaqih Mahmoud A

Abstract excerpt

BACKGROUND: Several studies have revealed that chromatin modifications lead to activation or repression of multiple genes including oncogenes and tumor suppressor genes. Inactivation mutation in EZH2 gene would result in activation of oncogenes. The aim of this case-control study was to identify mutations in the EZH2 gene, to study their prevalence among Jordanian patients with colorectal adenoma and to determine...

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Identifiers

PMID: 34967593
DOI: 10.31557/APJCP.2021.22.12.4085
PMCID: PMC9080367

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