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Article

Determining the origin of synchronous multifocal bladder cancer by exome sequencing.

BMC cancer - 9 Nov 2015

Acar Ömer, Özkurt Ezgi, Demir Gulfem, Saraç Hilal, Alkan Can, Esen Tarık, Somel Mehmet, Lack Nathan A

Abstract excerpt

BACKGROUND: Synchronous multifocal tumours are commonly observed in urothelial carcinomas of the bladder. The origin of these physically independent tumours has been proposed to occur by either intraluminal migration (clonal) or spontaneous transformation of multiple cells by carcinogens (field effect). It is unclear which model is correct, with several studies supporting both hypotheses. A potential cause of...

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Identifiers

PMID: 26553077
DOI: 10.1186/s12885-015-1859-8
PMCID: PMC4638097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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