Article
SWI/SNF-mutant cancers depend on catalytic and non-catalytic activity of EZH2.
Nature medicine - 1 Dec 2015
Kim Kimberly H, Kim Woojin, Howard Thomas P, Vazquez Francisca, Tsherniak Aviad, Wu Jennifer N, Wang Weishan, Haswell Jeffrey R, Walensky Loren D, Hahn William C, Orkin Stuart H, Roberts Charles W M
Abstract excerpt
Human cancer genome sequencing has recently revealed that genes that encode subunits of SWI/SNF chromatin remodeling complexes are frequently mutated across a wide variety of cancers, and several subunits of the complex have been shown to have bona fide tumor suppressor activity. However, whether mutations in SWI/SNF subunits result in shared dependencies is unknown. Here we show that EZH2, a catalytic subunit of...
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