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Article

Computational studies on translocator protein (TSPO) and its ligands.

Current topics in medicinal chemistry - 1 Jan 2012

Ortore Gabriella, Tuccinardi Tiziano, Martinelli Adriano

Abstract excerpt

The Translocator Protein (18 kDa) (TSPO), previously known as the peripheral benzodiazepine receptor, is widely expressed in glial cells and in peripheral tissues and is involved in a variety of biological processes: steroidogenesis, cell growth and differentiation, apoptosis induction, etc. TSPO basal expression is up-regulated in a number of human pathologies, including a variety of tumors and neuropathologies,...

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Source

Identifiers

PMID: 22204485
DOI: 10.2174/156802612799078667

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Computational studies on translocator protein (TSPO) and its ligands.PMID 22204485Read ↗

Radiolabelled Molecules for Imaging the Translocator Protein (18 kDa) Using Positron Emission TomographySemantic proximity Read ↗

Essential Principles and Recent Progress in the Development of TSPO PET Ligands for Neuroinflammation ImagingSemantic proximity Read ↗

Guwiyang Wurra--'Fire Mouse': a global gene knockout model for TSPO/PBR drug development, loss-of-function and mechanisms of compensation studies.Semantic proximity Read ↗

The Role of Translocator Protein TSPO in Hallmarks of GlioblastomaSemantic proximity Read ↗

Development of N-methyl-(2-arylquinolin-4-yl)oxypropanamides as leads to PET radioligands for translocator protein (18 kDa).Semantic proximity Read ↗

Translocator protein ligand Ro5-4864 promotes melanogenesis in a TSPO independent mannerSemantic proximity Read ↗

Protein structure. Crystal structures of translocator protein (TSPO) and mutant mimic of a human polymorphism.Semantic proximity Read ↗

Development and evaluation of [11C]DPA-813 and [18F]DPA-814: novel TSPO PET tracers insensitive to human single nucleotide polymorphism rs6971.Semantic proximity Read ↗

[18F]VUIIS1009B Features a Superior Imaging Performance to [18F]DPA-714 in TSPO Density Characterization for Neuroinflammatory PET ImagingSemantic proximity Read ↗

Translocator Protein (18 kDa) Polymorphism (rs6971) Explains <i>in-vivo</i> Brain Binding Affinity of the PET Radioligand [ <sup>18</sup> F]-FEPPASemantic proximity Read ↗

Tricyclic heterocycles display diverse sensitivity to the A147T TSPO polymorphism.Semantic proximity Read ↗

Variation rs6971 in the Translocator Protein Gene (TSPO) is Associated with Aggressiveness and Impulsivity but Not with Anxiety in a Population-Representative Sample of Young Adults.Semantic proximity Read ↗

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