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Article

Development of N-methyl-(2-arylquinolin-4-yl)oxypropanamides as leads to PET radioligands for translocator protein (18 kDa).

Journal of medicinal chemistry - 24 Jul 2014

Brouwer Chad, Jenko Kimberly, Zoghbi Sami S, Innis Robert B, Pike Victor W

Abstract excerpt

Translocator protein (18 kDa), known as TSPO, is a recognized biomarker of neuroinflammation. Radioligands with PET accurately quantify TSPO in neuroinflammatory conditions. However, the existence of three human TSPO genotypes that show differential affinity to almost all useful TSPO PET radiolig...

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Source

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Identifiers

PMID: 24949670
DOI: 10.1021/jm5007947
PMCID: PMC4216211

Genes

TSPO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24949670-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Development of N-methyl-(2-arylquinolin-4-yl)oxypropanamides as leads to PET radioligands for translocator protein (18 kDa).PMID 24949670Read ↗

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Translocator Protein (18 kDa) Polymorphism (rs6971) Explains <i>in-vivo</i> Brain Binding Affinity of the PET Radioligand [ <sup>18</sup> F]-FEPPASemantic proximity Read ↗

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