Article
Genomic profiling of Sézary syndrome identifies alterations of key T cell signaling and differentiation genes.
Nature genetics - 1 Dec 2015
Wang Linghua, Ni Xiao, Covington Kyle R, Yang Betty Y, Shiu Jessica, Zhang Xiang, Xi Liu, Meng Qingchang, Langridge Timothy, Drummond Jennifer, Donehower Lawrence A, Doddapaneni Harshavardhan, Muzny Donna M, Gibbs Richard A, Wheeler David A, Duvic Madeleine
Abstract excerpt
Sézary syndrome is a rare leukemic form of cutaneous T cell lymphoma characterized by generalized redness, scaling, itching and increased numbers of circulating atypical T lymphocytes. It is rarely curable, with poor prognosis. Here we present a multiplatform genomic analysis of 37 patients with Sézary syndrome that implicates dysregulation of cell cycle checkpoint and T cell signaling. Frequent somatic...
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