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Article

Candidate driver genes involved in genome maintenance and DNA repair in Sézary syndrome

28 Apr 2016

Abstract excerpt

Sézary syndrome (SS) is a leukemic variant of cutaneous T-cell lymphoma (CTCL) and represents an ideal model for study of T-cell transformation. We describe whole-exome and single-nucleotide polymorphism array-based copy number analyses of CD4(+) tumor cells from untreated patients at diagnosis and targeted resequencing of 101 SS cases. A total of 824 somatic nonsynonymous gene variants were identified including...

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PMID: 27121473
DOI: 10.1182/blood-2016-02-699843

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