Article
Genomic landscape of cutaneous T cell lymphoma.
Nature genetics - 1 Sept 2015
Choi Jaehyuk, Goh Gerald, Walradt Trent, Hong Bok S, Bunick Christopher G, Chen Kan, Bjornson Robert D, Maman Yaakov, Wang Tiffany, Tordoff Jesse, Carlson Kacie, Overton John D, Liu Kristina J, Lewis Julia M, Devine Lesley, Barbarotta Lisa, Foss Francine M, Subtil Antonio, Vonderheid Eric C, Edelson Richard L, Schatz David G, Boggon Titus J, Girardi Michael, Lifton Richard P
Abstract excerpt
Cutaneous T cell lymphoma (CTCL) is a non-Hodgkin lymphoma of skin-homing T lymphocytes. We performed exome and whole-genome DNA sequencing and RNA sequencing on purified CTCL and matched normal cells. The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-κB signaling, chromatin remodeling and DNA damage response. CTCL is distinctive in...
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