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Article

Multiomic study of cutaneous T-cell lymphoma reveals single-cell clonal evolution in progression and therapy resistance.

Blood - 21 May 2026

Dorando Hannah K, Andrews Jared M, Khatavkar Oam U, Borcherding Nicholas C, Korshunova Yulia, Hakeman Gabriela, Panigassi Rodrigo, Vo Phuong, Tu Ruei-Yuan, Tran Diep, Quinn Chaz C, Schmidt Jennifer A, Aluri Jahnavi, Harmon Michael T, Watkins Marcus P, Frank Anastasia, Cooper Megan A, Musiek Amy C, Mehta-Shah Neha, Payton Jacqueline E

Abstract excerpt

ABSTRACT: Cutaneous T-cell lymphoma (CTCL) remains a challenging disease due to its significant heterogeneity, therapy resistance, and relentless progression. Multiomics technologies offer the potential to provide uniquely precise views of disease progression and response to therapy. Here, we present a comprehensive multiomics view of CTCL clonal evolution, incorporating exome, whole-genome, epigenome, bulk,...

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Topics

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Share to Clonal Evolution
Share to Disease Progression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Neoplasm

Share to Lymphoma, T-Cell, Cutaneous

Share to Multiomics

Share to Single-Cell Analysis

Share to Single-Cell Gene Expression Analysis

Share to Skin Neoplasms

Source

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Identifiers

PMID: 41662591
DOI: 10.1182/blood.2025029012
PMCID: PMC13197982

Genes

CCR4
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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