Allogeneic Stem Cell Transplantation Improves Survival in Patients with Acute Myeloid Leukemia Characterized by a High Allelic Ratio of Mutant FLT3-ITD.

doi:10.1016/j.bbmt.2015.10.023

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Article

Allogeneic Stem Cell Transplantation Improves Survival in Patients with Acute Myeloid Leukemia Characterized by a High Allelic Ratio of Mutant FLT3-ITD.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Mar 2016

Ho Anthony D, Schetelig Johannes, Bochtler Tilmann, Schaich Markus, Schäfer-Eckart Kerstin, Hänel Mathias, Rösler Wolf, Einsele Hermann, Kaufmann Martin, Serve Hubert, Berdel Wolfgang E, Stelljes Matthias, Mayer Jiri, Reichle Albrecht, Baldus Claudia D, Schmitz Norbert, Kramer Michael, Röllig Christoph, Bornhäuser Martin, Thiede Christian, Ehninger Gerhard

Abstract excerpt

Allogeneic hematopoietic cell transplantation (alloHCT) as a postremission therapy in patients with FLT3-ITD-positive intermediate-risk acute myeloid leukemia (AML) remains controversial. FLT3-ITD mutations are heterogeneous with respect to allelic ratio, location, and length of the insertion, with a high mutant-to-wild-type ratio consistently associated with inferior prognosis. We retrospectively analyzed the...

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Identifiers

PMID: 26551637
DOI: 10.1016/j.bbmt.2015.10.023

Genes

FLT3
NPM1
EFS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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