Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation.

doi:10.1182/blood-2014-05-578070

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Article

Differential impact of allelic ratio and insertion site in FLT3-ITD-positive AML with respect to allogeneic transplantation.

Blood - 27 Nov 2014

Schlenk Richard F, Kayser Sabine, Bullinger Lars, Kobbe Guido, Casper Jochen, Ringhoffer Mark, Held Gerhard, Brossart Peter, Lübbert Michael, Salih Helmut R, Kindler Thomas, Horst Heinz A, Wulf Gerald, Nachbaur David, Götze Katharina, Lamparter Alexander, Paschka Peter, Gaidzik Verena I, Teleanu Veronica, Späth Daniela, Benner Axel, Krauter Jürgen, Ganser Arnold, Döhner Hartmut, Döhner Konstanze

Abstract excerpt

The objective was to evaluate the prognostic and predictive impact of allelic ratio and insertion site (IS) of internal tandem duplications (ITDs), as well as concurrent gene mutations, with regard to postremission therapy in 323 patients with FLT3-ITD-positive acute myeloid leukemia (AML). Increasing FLT3-ITD allelic ratio (P = .004) and IS in the tyrosine kinase domain 1 (TKD1, P = .06) were associated with low...

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Identifiers

PMID: 25270908
DOI: 10.1182/blood-2014-05-578070

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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