Distinct clinico-biological features in AML patients with low allelic ratio FLT3-ITD: role of allogeneic stem cell transplantation in first remission.

doi:10.1038/s41409-021-01454-z

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Distinct clinico-biological features in AML patients with low allelic ratio FLT3-ITD: role of allogeneic stem cell transplantation in first remission.

Bone marrow transplantation - 1 Jan 2022

Tien Feng-Ming, Tsai Xavier Cheng-Hong, Huang Sheng-Chuan, Liu Jia-Hau, Chen Chien-Yuan, Kuo Yuan-Yeh, Chuang Yi-Kuang, Tseng Mei-Hsuan, Peng Yen-Ling, Liu Ming-Chih, Liu Chia-Wen, Liao Xiu-Wen, Lin Liang-In, Wu Yu-Sin, Hou Mei-Fang, Wu Shang-Ju, Hsu Szu-Chun, Ko Bor-Sheng, Chou Wen-Chien, Yao Ming, Hou Hsin-An, Tang Jih-Luh, Tien Hwei-Fang

Abstract excerpt

The mutant burden of FLT3-ITD modulates its prognostic impact on patients with acute myeloid leukemia (AML). However, for patients with low allelic ratio (AR) FLT3-ITD (FLT3-ITDlow, AR < 0.5), clinical features, as well as genomic and transcriptomic profiles remain unclear, and evidence supporting allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first complete remission (CR1) remains...

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PMID: 34671120
DOI: 10.1038/s41409-021-01454-z

Genes

FLT3
CR1
AR
EFS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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