Article
8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype.
International archives of occupational and environmental health - 1 Jan 2007
Lee Chul-Ho, Kamijima Michihiro, Kim Heon, Shibata Eiji, Ueyama Jun, Suzuki Takayoshi, Takagi Kenji, Saito Isao, Gotoh Masahiro, Hibi Hatsuki, Naito Hisao, Nakajima Tamie
Abstract excerpt
OBJECTIVE: In order to investigate a role of paraoxonase 1 (PON1) polymorphism in organophosphorus (OP)-induced 8-hydroxydeoxyguanosine (8-OHdG) levels, urinary metabolites of OP, PON1 genotypes, and 8-OHdG levels in leukocyte and urine were measured in OP indoor insecticide sprayers and controls in summer and winter. METHODS: The study population contained 18 male sprayers and age-matched 18 male controls....
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