Article
Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides.
Toxicology and applied pharmacology - 15 Nov 2011
Singh Satyender, Kumar Vivek, Vashisht Kapil, Singh Priyanka, Banerjee Basu Dev, Rautela Rajender Singh, Grover Shyam Sunder, Rawat Devendra Singh, Pasha Syed Tazeen, Jain Sudhir Kumar, Rai Arvind
Abstract excerpt
Organophosphate pesticides (OPs) are primarily metabolized by several xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticide-exposed workers. The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers...
Topics
- Aryl Hydrocarbon Hydroxylases
- Aryldialkylphosphatase
- Comet Assay
- Cytochrome P-450 CYP1A1
- Cytochrome P-450 CYP2C9
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP3A
- DNA Damage
- Genotype
- Humans
- Middle Aged
- Occupational Exposure