Article
Role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers occupationally exposed to organophosphate pesticides.
Toxicology and applied pharmacology - 15 Nov 2011
Singh Satyender, Kumar Vivek, Vashisht Kapil, Singh Priyanka, Banerjee Basu Dev, Rautela Rajender Singh, Grover Shyam Sunder, Rawat Devendra Singh, Pasha Syed Tazeen, Jain Sudhir Kumar, Rai Arvind
Abstract excerpt
Organophosphate pesticides (OPs) are primarily metabolized by several xenobiotic metabolizing enzymes (XMEs). Very few studies have explored genetic polymorphisms of XMEs and their association with DNA damage in pesticide-exposed workers. The present study was designed to determine the role of genetic polymorphisms of CYP1A1, CYP3A5, CYP2C9, CYP2D6, and PON1 in the modulation of DNA damage in workers...
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