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Article

Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.

Cell - 19 Nov 2015

Ru Heng, Chambers Melissa G, Fu Tian-Min, Tong Alexander B, Liao Maofu, Wu Hao

Abstract excerpt

Diverse repertoires of antigen-receptor genes that result from combinatorial splicing of coding segments by V(D)J recombination are hallmarks of vertebrate immunity. The (RAG1-RAG2)2 recombinase (RAG) recognizes recombination signal sequences (RSSs) containing a heptamer, a spacer of 12 or 23 base pairs, and a nonamer (12-RSS or 23-RSS) and introduces precise breaks at RSS-coding segment junctions. RAG forms...

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Source

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Identifiers

PMID: 26548953
DOI: 10.1016/j.cell.2015.10.055
PMCID: PMC4690471

Genes

RAG1
RAG2
HMGB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Molecular Mechanism of V(D)J Recombination from Synaptic RAG1-RAG2 Complex Structures.PMID 26548953Read ↗

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