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Article

Crystal structure of the V(D)J recombinase RAG1-RAG2.

Nature - 26 Feb 2015

Kim Min-Sung, Lapkouski Mikalai, Yang Wei, Gellert Martin

Abstract excerpt

V(D)J recombination in the vertebrate immune system generates a highly diverse population of immunoglobulins and T-cell receptors by combinatorial joining of segments of coding DNA. The RAG1-RAG2 protein complex initiates this site-specific recombination by cutting DNA at specific sites flanking the coding segments. Here we report the crystal structure of the mouse RAG1-RAG2 complex at 3.2 Å resolution. The...

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Source

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Identifiers

PMID: 25707801
DOI: 10.1038/nature14174
PMCID: PMC4342785

Genes

RAG1
RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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