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Article

Detection of RNA-Protein Interactions in Living Cells with SHAPE.

Biochemistry - 24 Nov 2015

Smola Matthew J, Calabrese J Mauro, Weeks Kevin M

Abstract excerpt

SHAPE-MaP is unique among RNA structure probing strategies in that it both measures flexibility at single-nucleotide resolution and quantifies the uncertainties in these measurements. We report a straightforward analytical framework that incorporates these uncertainties to allow detection of RNA structural differences between any two states, and we use it here to detect RNA-protein interactions in healthy mouse...

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PMID: 26544910
DOI: 10.1021/acs.biochem.5b00977
PMCID: PMC4900165

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