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Article

On the modelling of variance components in classical twin studies.

Journal of human genetics - 1 May 2026

Hussain Shobbir

Abstract excerpt

Classical twin studies can be used to disentangle the extent to which phenotypic variance of a given complex trait is determined by genetic and environmental variance. The designs widely employ 'ACDE' structural equation models where partitioned variances, including that of additive (A) and dominance (D) genetic components, are estimated and where A is taken as reflective of the narrow-sense heritability. Here,...

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Identifiers

PMID: 41188447
DOI: 10.1038/s10038-025-01427-w
PMCID: PMC13109050

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