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Article

Open problems in human trait genetics.

Genome biology - 20 Jun 2022

Brandes Nadav, Weissbrod Omer, Linial Michal

Abstract excerpt

Genetic studies of human traits have revolutionized our understanding of the variation between individuals, and yet, the genetics of most traits is still poorly understood. In this review, we highlight the major open problems that need to be solved, and by discussing these challenges provide a primer to the field. We cover general issues such as population structure, epistasis and gene-environment interactions,...

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Identifiers

PMID: 35725481
DOI: 10.1186/s13059-022-02697-9
PMCID: PMC9208223

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