Article

Mechanism of the Switch from NO to H <sub>2</sub> O <sub>2</sub> in Endothelium-Dependent Vasodilation in Diabetes

2021-05-18

Abstract excerpt

Coronary microvascular dysfunction is prevalent among diabetics and is correlated with cardiac mortality. Compromised endothelial-dependent dilation (EDD) is an early event in the progression of diabetes, but the mechanisms remain incompletely understood. Nitric oxide (NO) is the major endothelium-dependent vasodilatory metabolite in the healthy coronary circulation, but switches to hydrogen peroxide (H 2 O 2 )...

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Literature Corpus work: 9e034305-3952-5e5d-bd0c-5cab6fb9da1e
DOI: 10.1101/2021.05.18.444667

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