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Article

Endothelial TERT drives microvascular phenotype associated with coronary artery disease.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2025

Birch Erin C, Nishijima Yoshinori, Hader Shelby N, Beyer Andreas M

Abstract excerpt

Microvascular endothelial dysfunction is a powerful predictor of future atherosclerotic cardiac events. Our previous studies revealed that under pathological states, such as coronary artery disease (CAD), the dilation mechanism switches from nitric oxide (NO)-mediated [determined by NO synthase (NOS) inhibitor] to mitochondria-derived H2O2 (determined by H2O2 scavenger). Telomerase reverse transcriptase (TERT),...

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Identifiers

PMID: 40514200
DOI: 10.1152/ajpheart.00342.2025
PMCID: PMC12233018

Genes

TERT
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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