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Article

TNIK inhibition abrogates colorectal cancer stemness.

Nature communications - 26 Aug 2016

Masuda Mari, Uno Yuko, Ohbayashi Naomi, Ohata Hirokazu, Mimata Ayako, Kukimoto-Niino Mutsuko, Moriyama Hideki, Kashimoto Shigeki, Inoue Tomoko, Goto Naoko, Okamoto Koji, Shirouzu Mikako, Sawa Masaaki, Yamada Tesshi

Abstract excerpt

Canonical Wnt/β-catenin signalling is essential for maintaining intestinal stem cells, and its constitutive activation has been implicated in colorectal carcinogenesis. We and others have previously identified Traf2- and Nck-interacting kinase (TNIK) as an essential regulatory component of the T-cell factor-4 and β-catenin transcriptional complex. Consistent with this, Tnik-deficient mice are resistant to...

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Identifiers

PMID: 27562646
DOI: 10.1038/ncomms12586
PMCID: PMC5007443

Genes

TNIK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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