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Article

Wnt signaling as a therapeutic target for cancer.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2007

Herbst Andreas, Kolligs Frank Thomas

Abstract excerpt

The Wnt/beta-catenin signaling pathway is tightly regulated and has important functions in development, tissue homeostasis, and regeneration. Deregulation of Wnt/beta-catenin signaling is frequently found in various human cancers. Eighty percent of colorectal cancers alone reveal activation of this pathway by either inactivation of the tumor-suppressor gene adenomatous polyposis coli or mutation of the...

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Identifiers

PMID: 17172707
DOI: 10.1385/1-59745-208-4:63

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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