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Article

The human rs1050286 polymorphism alters LOX-1 expression through modifying miR-24 binding.

Journal of cellular and molecular medicine - 1 Jan 2016

Morini Elena, Rizzacasa Barbara, Pucci Sabina, Polidoro Chiara, Ferrè Fabrizio, Caporossi Daniela, Helmer Citterich Manuela, Novelli Giuseppe, Amati Francesca

Abstract excerpt

The up-regulation of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, plays a fundamental role in the pathogenesis of atherosclerosis. Moreover, OLR1 polymorphisms were associated with increased susceptibility to acute myocardial infarction (AMI) and coronary artery diseases (CAD). In these pathologies, the identification of therapeutic approaches that can inhibit or...

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Source

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Identifiers

PMID: 26542080
DOI: 10.1111/jcmm.12716
PMCID: PMC4717858

Genes

OLR1
LOX
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The human rs1050286 polymorphism alters LOX-1 expression through modifying miR-24 binding.PMID 26542080Read ↗

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Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease.Semantic proximity Read ↗

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