Article
In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction.
Circulation research - 22 Jul 2005
Mango Ruggiero, Biocca Silvia, del Vecchio Francesca, Clementi Fabrizio, Sangiuolo Federica, Amati Francesca, Filareto Antonio, Grelli Sandro, Spitalieri Paola, Filesi Ilaria, Favalli Cartesio, Lauro Renato, Mehta Jawahar L, Romeo Francesco, Novelli Giuseppe
Abstract excerpt
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), encoded by the OLR1 gene, is a scavenger receptor that plays a fundamental role in the pathogenesis of atherosclerosis. LOX-1 activation is associated with apoptosis of endothelial cells, smooth muscle cells (SMCs), and macrophages. This process is an important underlying mechanism that contributes to plaque instability and subsequent development of...
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