Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LOX-1 and Its Splice Variants: A New Challenge for Atherosclerosis and Cancer-Targeted Therapies.

International journal of molecular sciences - 29 Jan 2017

Rizzacasa Barbara, Morini Elena, Pucci Sabina, Murdocca Michela, Novelli Giuseppe, Amati Francesca

Abstract excerpt

Alternative splicing (AS) is a process in which precursor messenger RNA (pre-mRNA) splicing sites are differentially selected to diversify the protein isoform population. Changes in AS patterns have an essential role in normal development, differentiation and response to physiological stimuli. It is documented that AS can generate both "risk" and "protective" splice variants that can contribute to the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Atherosclerosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Transformation, Neoplastic

Share to Molecular Targeted Therapy

Share to Neoplasms

Share to Protein Isoforms

Share to RNA Splicing

Share to Scavenger Receptors, Class E

Source

Open in PubMed Open full text

Identifiers

PMID: 28146073
DOI: 10.3390/ijms18020290
PMCID: PMC5343826

Genes

OLR1
LOX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LOX-1 and Its Splice Variants: A New Challenge for Atherosclerosis and Cancer-Targeted Therapies.PMID 28146073Read ↗

LOX-1 variants modulate the severity of cardiovascular disease: state of the art and future directions.Semantic proximity Read ↗

LOX-1/LOXIN: the yin/yang of atheroscleorosis.Semantic proximity Read ↗

Association of OLR1 gene polymorphisms with the risk of coronary artery disease: A systematic review and meta-analysis.Semantic proximity Read ↗

The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization.Semantic proximity Read ↗

Role of six single nucleotide polymorphisms, risk factors in coronary disease, in OLR1 alternative splicing.Semantic proximity Read ↗

Upregulated LOX-1 Receptor: Key Player of the Pathogenesis of AtherosclerosisSemantic proximity Read ↗

In vivo and in vitro studies support that a new splicing isoform of OLR1 gene is protective against acute myocardial infarction.Semantic proximity Read ↗

The human rs1050286 polymorphism alters LOX-1 expression through modifying miR-24 binding.Semantic proximity Read ↗

The role of splicing events in the inflammatory response of atherosclerosis: molecular mechanisms and modulationSemantic proximity Read ↗

The Two Variants of Oxysterol Binding Protein-related Protein-1 Display Different Tissue Expression Patterns, Have Different Intracellular Localization, and Are Functionally DistinctSemantic proximity Read ↗

Clinical and Preclinical Use of LOX-1-Specific Antibodies in Diagnostics and TherapeuticsSemantic proximity Read ↗

LDL Receptor–Related Protein-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.