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Article

MRP1 and its role in anticancer drug resistance

2 Oct 2015

Abstract excerpt

The phenomenon of multidrug resistance (MDR) in cancer is associated with the overexpression of the ATP-binding cassette (ABC) transporter proteins, including multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein. MRP1 plays an active role in protecting cells by its ability to efflux a vast array of drugs to sub-lethal levels. There has been much effort in elucidating the mechanisms of action,...

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PMID: 26541366
DOI: 10.3109/03602532.2015.1105253

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