Article
Intracellular trafficking of MDR transporters and relevance of SNPs.
Current topics in medicinal chemistry - 1 Jan 2009
Porcelli Letizia, Lemos Clara, Peters Godefridus J, Paradiso Angelo, Azzariti Amalia
Abstract excerpt
Multi-drug resistance (MDR) frequently contributes to the failure of chemotherapeutic treatments in cancer patients. Mechanisms underlying the development of MDR have been extensively studied and are considered multifactorial. Among them, the ATP-Binding Cassette (ABC) family of proteins plays a...
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