Article
Transport of glutathione and glutathione conjugates by MRP1.
Trends in pharmacological sciences - 1 Aug 2006
Cole Susan P C, Deeley Roger G
Abstract excerpt
Glutathione (GSH)-conjugated xenobiotics and GSH-conjugated metabolites (e.g. the cysteinyl leukotriene C4) must be exported from the cells in which they are formed before they can be eliminated from the body or act on their cellular targets. This efflux is often mediated by the multidrug resistance protein 1 (MRP1) transporter, which also confers drug resistance to tumour cells and can protect normal cells from...
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