Article
Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians.
Mechanisms of ageing and development - 1 Feb 2005
Franceschi Claudio, Olivieri Fabiola, Marchegiani Francesca, Cardelli Maurizio, Cavallone Luca, Capri Miriam, Salvioli Stefano, Valensin Silvana, De Benedictis Giovanna, Di Iorio Angelo, Caruso Calogero, Paolisso Giuseppe, Monti Daniela
Abstract excerpt
In this paper, we review data of recent literature on the distribution in centenarians of candidate germ-line polymorphisms that likely affect the individual chance to reach the extreme limit of human life. On the basis of previous observations on the immunology, endocrinology and cellular biology of centenarians we focused on genes that regulate immune responses and inflammation (IL-6, IL-1 cluster, IL-10),...
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