Article
Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
Mutation research - 10 Dec 2010
Flachsbart Friederike, Franke Andre, Kleindorp Rabea, Caliebe Amke, Blanché Hélène, Schreiber Stefan, Nebel Almut
Abstract excerpt
Twin studies have shown that longevity in humans is moderately heritable with a genetic component of 25-32%. Experimental model organisms point to the existence of core survival and anti-ageing pathways that have been conserved throughout evolution. It has been shown that mutations in single genes involved in these pathways can either delay or accelerate the ageing process and that many of these genes and...
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