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Targeted Locus Amplification and Haplotyping.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2023

Lefferts Juliet W, Boersma Vera, Hagemeijer Marne C, Hajo Karima, Beekman Jeffrey M, Splinter Erik

Abstract excerpt

Targeted locus amplification (TLA) allows for the detection of all genetic variation (including structural variation) in a genomic region of interest. As TLA is based on proximity ligation, variants can be linked to each other, thereby enabling allelic phasing and the generation of haplotypes. This allows for the study of genetic variants in an allele-specific manner. Here, we provide a step-by-step protocol for...

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PMID: 36335490
DOI: 10.1007/978-1-0716-2819-5_2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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