Article
An NF-κB-microRNA regulatory network tunes macrophage inflammatory responses.
Nature communications - 11 Oct 2017
Mann Mati, Mehta Arnav, Zhao Jimmy L, Lee Kevin, Marinov Georgi K, Garcia-Flores Yvette, Lu Li-Fan, Rudensky Alexander Y, Baltimore David
Abstract excerpt
The innate inflammatory response must be tightly regulated to ensure effective immune protection. NF-κB is a key mediator of the inflammatory response, and its dysregulation has been associated with immune-related malignancies. Here, we describe a miRNA-based regulatory network that enables precise NF-κB activity in mouse macrophages. Elevated miR-155 expression potentiates NF-κB activity in miR-146a-deficient...
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