Article
MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation.
Immunity - 1 May 2008
Dorsett Yair, McBride Kevin M, Jankovic Mila, Gazumyan Anna, Thai To-Ha, Robbiani Davide F, Di Virgilio Michela, Reina San-Martin Bernardo, Heidkamp Gordon, Schwickert Tanja A, Eisenreich Thomas, Rajewsky Klaus, Nussenzweig Michel C
Abstract excerpt
MicroRNAs (miRNAs) are small noncoding RNAs that regulate vast networks of genes that share miRNA target sequences. To examine the physiologic effects of an individual miRNA-mRNA interaction in vivo, we generated mice that carry a mutation in the putative microRNA-155 (miR-155) binding site in th...
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