Article
Long non-coding RNA SeT and miR-155 regulate the Tnfα gene allelic expression profile.
PloS one - 1 Jan 2017
Stathopoulou Chrysoula, Kapsetaki Manouela, Stratigi Kalliopi, Spilianakis Charalampos
Abstract excerpt
It is becoming increasingly appreciated that the non-coding genome may have a great impact on the regulation of chromatin structure and gene expression. The innate immune response can be mediated upon lipopolysaccharide stimulation of macrophages which leads to immediate transcriptional activation of early responsive genes including tumor necrosis factor alpha (Tnfα). The functional role of non-coding RNAs, such...
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