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Article

GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells

2 Nov 2015

Abstract excerpt

Pseudostratified airway epithelium of the lung is composed of polarized ciliated and secretory cells maintained by basal stem/progenitor cells. An important question is how lineage choice and differentiation are coordinated with apical-basal polarity and epithelial morphogenesis. Our previous studies indicated a key integrative role for the transcription factor Grainyhead-like 2 (Grhl2). In this study, we present...

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PMID: 26527742
DOI: 10.1083/jcb.201506014

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