Article

Highly efficient genome editing in primary bronchial epithelial cells establishes FOXJ1 as essential for ciliation in human airways

2019-01-31

Abstract excerpt

The structure and composition of the bronchial epithelium is altered in respiratory diseases such as COPD and asthma, in which goblet cell hyperplasia and reduced numbers of ciliated cells impair mucociliary clearance. We describe a robust genome editing pipeline to interrogate modulators of primary human bronchial epithelial cell (HBEC) differentiation and function. By employing plasmid- and virus-free delivery o...

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Identifiers and source

Literature Corpus work: 11b69474-4f24-5dfc-9ded-9f1605cfb933
DOI: 10.1101/533869

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