Article

Generation of Region-specific Airway Basal Stem Cells from Human Pluripotent Stem Cells via Regulation of NOGGIN-BMP Axis

2025-10-01

Abstract excerpt

<h4>SUMMARY</h4> Basal cells (BCs) are the primary stem cell population of adult human airways and a key target for hPSC-based models of airway development, disease and regenerative medicine. Recent studies have revealed substantial regional differences between human proximal and distal airway cell types, including BCs. Here, we show that the NOGGIN-BMP signaling axis governs proximal-distal patterning of hPSC-de...

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Literature Corpus work: 70b9d356-cd2a-507f-8743-13a3d2bbdf0f
DOI: 10.1101/2025.10.01.657190

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