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Article

Basal cells as stem cells of the mouse trachea and human airway epithelium

22 Jul 2009

Abstract excerpt

The pseudostratified epithelium of the mouse trachea and human airways contains a population of basal cells expressing Trp-63 (p63) and cytokeratins 5 (Krt5) and Krt14. Using a KRT5-CreER(T2) transgenic mouse line for lineage tracing, we show that basal cells generate differentiated cells during postnatal growth and in the adult during both steady state and epithelial repair. We have fractionated mouse basal...

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PMID: 19625615
DOI: 10.1073/pnas.0906850106

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