Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nascent RNA folding mitigates transcription-associated mutagenesis.

Genome research - 1 Jan 2016

Chen Xiaoshu, Yang Jian-Rong, Zhang Jianzhi

Abstract excerpt

Transcription is mutagenic, in part because the R-loop formed by the binding of the nascent RNA with its DNA template exposes the nontemplate DNA strand to mutagens and primes unscheduled error-prone DNA synthesis. We hypothesize that strong folding of nascent RNA weakens R-loops and hence decreases mutagenesis. By a yeast forward mutation assay, we show that strengthening RNA folding and reducing R-loop...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Transport Systems, Basic
Share to Databases, Genetic
Share to DNA, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Mutagenesis

Share to Ribonuclease H

Share to RNA Folding

Share to Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 26518484
DOI: 10.1101/gr.195164.115
PMCID: PMC4691750

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nascent RNA folding mitigates transcription-associated mutagenesis.PMID 26518484Read ↗

The landscape of transcription errors in eukaryotic cells.Semantic proximity Read ↗

Introns Protect Eukaryotic Genomes from Transcription-Associated Genetic Instability.Semantic proximity Read ↗

Gene expression levels modulate germline mutation rates through the compound effects of transcription-coupled repair and damage.Semantic proximity Read ↗

Ribonucleotides and Transcription-Associated Mutagenesis in Yeast.Semantic proximity Read ↗

Transcription-associated mutagenesis increases protein sequence diversity more effectively than does random mutagenesis in Escherichia coli.Semantic proximity Read ↗

Gene expression levels tune germline mutation rates through the compound effects of transcription-coupled repair and damageSemantic proximity Read ↗

RNA meets DNA: The Potential for gene expression to produce short RNA molecules capable of generating DNA mutation and driving genome evolution (Comment on DOI: 10.1002/bies.201700069).Semantic proximity Read ↗

EGFP Reporters for Direct and Sensitive Detection of Mutagenic Bypass of DNA Lesions.Semantic proximity Read ↗

Transfer RNA genes experience exceptionally elevated mutation rates.Semantic proximity Read ↗

Transcription coupled repair and its impact on mutagenesis.Semantic proximity Read ↗

Loss of Elongation-Like Factor 1 Spontaneously Induces Diverse, RNase H-Related Suppressor Mutations in Schizosaccharomyces pombe.Semantic proximity Read ↗

Proper control of R-loop homeostasis is required for maintenance of gene expression and neuronal function during agingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.