Article

Gene expression levels tune germline mutation rates through the compound effects of transcription-coupled repair and damage

2021-05-27

Abstract excerpt

<title>Abstract</title> <p>Of all mammalian organs, the testis has long been observed to have the most diverse gene expression profile. To account for this widespread gene expression, we have proposed a mechanism termed ‘transcriptional scanning’, which reduces germline mutation rates through transcription-coupled repair (TCR). Our hypothesis contrasts with an earlier observation that mutation rates are overall p...

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Literature Corpus work: ddc0ea76-6d46-5020-91a2-a3e809d81de5
DOI: 10.21203/rs.3.rs-540111/v1

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