Article
A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer.
Scientific reports - 20 May 2015
Al-Tassan Nada A, Whiffin Nicola, Hosking Fay J, Palles Claire, Farrington Susan M, Dobbins Sara E, Harris Rebecca, Gorman Maggie, Tenesa Albert, Meyer Brian F, Wakil Salma M, Kinnersley Ben, Campbell Harry, Martin Lynn, Smith Christopher G, Idziaszczyk Shelley, Barclay Ella, Maughan Timothy S, Kaplan Richard, Kerr Rachel, Kerr David, Buchanan Daniel D, Buchannan Daniel D, Win Aung Ko, Hopper John, Jenkins Mark, Lindor Noralane M, Newcomb Polly A, Gallinger Steve, Conti David, Schumacher Fred, Casey Graham, Dunlop Malcolm G, Tomlinson Ian P, Cheadle Jeremy P, Houlston Richard S
Abstract excerpt
Genome-wide association studies (GWAS) of colorectal cancer (CRC) have identified 23 susceptibility loci thus far. Analyses of previously conducted GWAS indicate additional risk loci are yet to be discovered. To identify novel CRC susceptibility loci, we conducted a new GWAS and performed a meta-analysis with five published GWAS (totalling 7,577 cases and 9,979 controls of European ancestry), imputing genotypes...
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