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Characterizing Genetic Susceptibility to Colorectal Cancer in Taiwan Through Genome-Wide Association Study.

Molecular carcinogenesis - 1 Jan 2025

Bau Da-Tian, Liu Ting-Yuan, Yang Jai-Sing, Chen William Tzu-Liang, Tsai Chia-Wen, Chang Wen-Shin, Ke Tao-Wei, Liao Chi-Chou, Chen Yu-Chia, Chang Yen-Ting, Tsai Fuu-Jen

Abstract excerpt

We conducted the first genome-wide association study (GWAS) of colorectal cancer (CRC) in Taiwan with 5342 cases and 61,015 controls. Ninety-two SNPs in three genomic regions reached genome-wide significance (p < 5 × 10-8). The lead SNPs in these three regions were: rs12778523 (OR = 1.18, 95% CI, 1.15-1.23, p = 4.51 × 10-13), an intergenic SNP between RNA5SP299 and LINC02676 at chromosome 10p14; rs647161...

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Identifiers

PMID: 39392253
DOI: 10.1002/mc.23823

Genes

BMP2
BMP4
CDH1
CDKN1A
CDKN2B
EIF3H
GPATCH1
HAO1
LAMC1
NOTCH4
PITX1
POLD3
POU2AF2
PREX1
ZMIZ1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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