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Article

Somatic Genomic and Transcriptomic Characterization of Primary Ovarian Serous Borderline Tumors and Low-Grade Serous Carcinomas.

The Journal of molecular diagnostics : JMD - 1 Apr 2024

Stružinská Ivana, Hájková Nikola, Hojný Jan, Krkavcová Eva, Michálková Romana, Bui Quang Hiep, Matěj Radoslav, Laco Jan, Drozenová Jana, Fabian Pavel, Škapa Petr, Špůrková Zuzana, Cibula David, Frühauf Filip, Jirásek Tomáš, Zima Tomáš, Méhes Gábor, Kendall Bártů Michaela, Němejcová Kristýna, Dundr Pavel

Abstract excerpt

Low-grade serous carcinoma (LGSC) may develop from serous borderline tumor (SBT) tissue, where the micropapillary type (mSBT) presents the highest risk for progression. The sensitivity of LGSC to standard chemotherapy is limited, so alternative therapeutic approaches, including targeted treatment, are needed. However, knowledge about the molecular landscape of LGSC and mSBT is limited. A sample set of 137...

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Azo Compounds
Cystadenocarcinoma, Serous
Genomics
Neoplasm Grading

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Proto-Oncogene Proteins B-raf

Ubiquitin Thiolesterase

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PMID: 38280423
DOI: 10.1016/j.jmoldx.2023.12.004

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