Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation and characterization of mice harboring a conditional CXCL12 allele.

The International journal of developmental biology - 1 Jan 2015

Hillmer Ryan E, Boisvert Joanne P, Cucciare Monica J, Dwinell Michael B, Joksimovic Milan

Abstract excerpt

The chemokine CXCL12 has important functions in immune and central nervous systems. Moreover, a global disruption of CXCL12 in mice results in perinatal lethality. To circumvent this impediment and provide a tool for analyzing CXCL12 functions in specific organ systems, we have generated a mouse line harboring a loxP-site flanked exon 2 of CXCL12. A germ line deleter, β-actin::cre was used to remove a CXCL12 exon...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Cerebellum
Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopaminergic Neurons

Share to Embryo, Mammalian

Share to Fluorescent Antibody Technique

Share to In Situ Hybridization

Source

Identifiers

PMID: 26505253
DOI: 10.1387/ijdb.140348mj

Genes

CXCL12
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation and characterization of mice harboring a conditional CXCL12 allele.PMID 26505253Read ↗

Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice.Semantic proximity Read ↗

Chemokine signaling in development and diseaseSemantic proximity Read ↗

Generation of Conditional Knockout Alleles for PRUNE-1.Semantic proximity Read ↗

Variation in zygotic CRISPR/Cas9 gene editing outcomes generates novel reporter and deletion alleles at the Gdf11 locus.Semantic proximity Read ↗

Ubiquitous overexpression of CXCL12 confers radiation protection and enhances mobilization of hematopoietic stem and progenitor cellsSemantic proximity Read ↗

Cxcr4 regulation of interneuron migration is disrupted in 22q11.2 deletion syndrome.Semantic proximity Read ↗

Tools for Cre-Mediated Conditional Deletion of Floxed Alleles from Developing Cerebellar Purkinje Cells.Semantic proximity Read ↗

CXCL14 as a Key Regulator of Neuronal Development: Insights from Its Receptor and Multi-Omics AnalysisSemantic proximity Read ↗

Abnormal cerebellar development and Purkinje cell defects in Lgl1-Pax2 conditional knockout mice.Semantic proximity Read ↗

Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis.Semantic proximity Read ↗

Myeloid conditional deletion and transgenic models reveal a threshold for the neutrophil survival factor Serpinb1.Semantic proximity Read ↗

Generation of conditional Hoxc8 loss-of-function and Hoxc8-->Hoxc9 replacement alleles in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.