Article
Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis.
Genesis (New York, N.Y. : 2000) - 1 Dec 2005
Yamashita Tadashi, Allende Maria Laura, Kalkofen Danielle N, Werth Norbert, Sandhoff Konrad, Proia Richard L
Abstract excerpt
Glycosphingolipids are organizational building blocks of plasma membranes that participate in key cellular functions, such as signaling and cell-to-cell interactions. Glucosylceramide synthase--encoded by the Ugcg gene--controls the first committed step in the major pathway of glycosphingolipid synthesis. Global disruption of the Ugcg gene in mice is lethal during gastrulation. We have now established a Ugcg...
Topics
- Alleles
- Animals
- Behavior, Animal
- Brain
- Crosses, Genetic
- Glucosyltransferases
- Glycosphingolipids
- Integrases
- Intermediate Filament Proteins
- Mice
- Mice, Knockout